Concerted Cyclization of Lanosterol C-Ring and D-Ring Under Human Oxidosqualene Cyclase Catalysis: An ab Initio QM/MM MD Study
Author:
Affiliation:
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China
2. Schrödinger, LLC., 120 West 45th Street, 17th Floor, New York, New York, 10036 United States
Publisher
American Chemical Society (ACS)
Subject
Physical and Theoretical Chemistry,Computer Science Applications
Link
https://pubs.acs.org/doi/pdf/10.1021/ct400949b
Reference86 articles.
1. The Biological Synthesis of Cholesterol
2. Regulation of the mevalonate pathway
3. Contribution of the shunt pathway of mevalonate metabolism to the regulation of cholesterol synthesis in rat liver.
4. Cholesterol interactions with phospholipids in membranes
5. Modulation of membrane function by cholesterol
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