An Oral Sphingosine 1-Phosphate Receptor 1 (S1P1) Antagonist Prodrug with Efficacy in Vivo: Discovery, Synthesis, and Evaluation
Author:
Affiliation:
1. Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm3009508
Reference37 articles.
1. Structural and functional characteristics of S1P receptors
2. Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
3. The alliance of sphingosine-1-phosphate and its receptors in immunity
4. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
5. The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
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