Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site-Reference-Cited by-同舟云学术

Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

Published:2014-02-06 Issue:4 Volume:57 Page:1390-1402
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Xiao-Feng¹²,Guan Fang¹,Ohkoshi Emika³,Guo Wanjun⁴,Wang Lili¹,Zhu Dong-Qing¹,Wang Sheng-Biao¹,Wang Li-Ting³,Hamel Ernest⁵,Yang Dexuan⁴,Li Linna⁴,Qian Keduo³,Morris-Natschke Susan L.³,Yuan Shoujun⁴,Lee Kuo-Hsiung³⁶,Xie Lan¹

Affiliation:

1. Beijing Institute of Pharmacology and Toxicology, 27 Tai-Ping Road, Beijing 100850, China

2. Pharmacy Department, Urumqi General Hospital, Lanzhou Military Region, Urumqi 830000, China

3. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina 27599, United States

4. Beijing Institute of Radiation Medicine, 27 Tai-Ping Road, Beijing 100850, China

5. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States

6. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4016526

Reference37 articles.

1. Microtubule-binding agents: a dynamic field of cancer therapeutics

2. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

3. Disrupting tumour blood vessels

4. A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment

Cited by 64 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy;European Journal of Medicinal Chemistry;2024-10

2. Design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential Werner-dependent antiproliferative agents;Molecular Diversity;2024-05-13

3. Design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential Werner-dependent anticancer agents;2024-01-09

4. A review of recent advances in quinoline/isoquinoline based hybrids as microtubule targeted cancer therapeutics: Synthesis, binding mode, QSAR and docking studies;Journal of Molecular Structure;2024-01

5. Discovery and Mechanistic Insights into Thieno[3,2-D]Pyrimidine and Heterocyclic Fused Pyrimidines Inhibitors Targeting Tubulin for Cancer Therapy;2024