Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections

Author:

Koh Jun-Jie12,Lin Shuimu13,Aung Thet Tun1,Lim Fanghui1,Zou Hanxun13,Bai Yang14,Li Jianguo15,Lin Huifen1,Pang Li Mei1,Koh Wee Luan1,Salleh Shuhaida Mohamed1,Lakshminarayanan Rajamani16,Zhou Lei16,Qiu Shengxiang7,Pervushin Konstantin4,Verma Chandra1548,Tan Donald T. H.2,Cao Derong3,Liu Shouping136,Beuerman Roger W.16

Affiliation:

1. Singapore Eye Research Institute, 11 Third Hospital Avenue, 168751, Singapore

2. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 119074, Singapore

3. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China

4. School of Biological Sciences, Nanyang Technological University, 637551, Singapore

5. Bioinformatics Institute, 138671, Singapore

6. SRP Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 169857, Singapore

7. South China Botanical Garden, Guangzhou 510650, China

8. Department of Biological Sciences, National University of Singapore, 117543, Singapore

Funder

SingHealth Foundation

Agency for Science, Technology and Research

National Medical Research Council

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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