Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies-Reference-Cited by-全球学者库

Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies

Published:2008-06-01 Issue:12 Volume:51 Page:3540-3554
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wen Xiaoan¹,Sun Hongbin¹,Liu Jun¹,Cheng Keguang¹,Zhang Pu¹,Zhang Liying¹,Hao Jia¹,Zhang Luyong¹,Ni Peizhou¹,Zographos Spyros E.¹,Leonidas Demetres D.¹,Alexacou Kyra-Melinda¹,Gimisis Thanasis¹,Hayes Joseph M.¹,Oikonomakos Nikos G.¹

Affiliation:

1. Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China, Jiangsu Center for Drug Screening, China Pharmaceutical University, 1 Shennonglu, Nanjing 210038, China, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece, and Organic Chemistry Laboratory, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8000949

Reference81 articles.

1. Specific features of glycogen metabolism in the liver

2. Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis

3. Glycogen phosphorylase inhibition as a therapeutic target: a review of the recent patent literature

4. Glycogen Phosphorylase as a Molecular Target for Type 2 Diabetes Therapy

5. Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo

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