Design, Synthesis, and Evaluation of New Thiadiazole-Based Direct Inhibitors of Enoyl Acyl Carrier Protein Reductase (InhA) for the Treatment of Tuberculosis-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of New Thiadiazole-Based Direct Inhibitors of Enoyl Acyl Carrier Protein Reductase (InhA) for the Treatment of Tuberculosis

Published:2014-12-29 Issue:2 Volume:58 Page:613-624
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Šink Roman¹,Sosič Izidor¹,Živec Matej¹,Fernandez-Menendez Raquel²,Turk Samo¹,Pajk Stane¹,Alvarez-Gomez Daniel²,Lopez-Roman Eva Maria²,Gonzales-Cortez Carolina²,Rullas-Triconado Joaquin²,Angulo-Barturen Inigo²,Barros David²,Ballell-Pages Lluís²,Young Robert J.³,Encinas Lourdes²,Gobec Stanislav¹

Affiliation:

1. Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenija

2. Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain

3. Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Funder

European Commission

Global Alliance for TB Drug Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501029r

Reference48 articles.

1. WHO Global Tuberculosis Report 2014;World Health Organization:Geneva, 2014; http://www.who.int/tb/publications/global_report/en/(accessed February 11, 2014).

2. Advancing the development of tuberculosis therapy

3. Extensively drug-resistant tuberculosis: current challenges and threats

4. Global Tuberculosis Report 2013;World Health Organization:Geneva, 2013; http://www.who.int/tb/publications/factsheet_global.pdf(accessed on February 11, 2014).

5. Totally Drug-Resistant Tuberculosis in India

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