Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search-Reference-Cited by-同舟云学术

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Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search

Published:2014-01-17 Issue:3 Volume:57 Page:1121-1126
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhuang Chunlin¹²,Narayanapillai Sreekanth¹,Zhang Wannian²,Sham Yuk Yin³,Xing Chengguo¹

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States

2. Department of Medicinal Chemistry, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People’s Republic of China

3. Center for Drug Design, University of Minnesota, 516 Delaware Street SE, Minneapolis, Minnesota 55455, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4017174

Reference21 articles.

1. Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

2. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

3. Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

4. Chemical and molecular regulation of enzymes that detoxify carcinogens.

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