Alzheimer’s Drug PBT2 Interacts with the Amyloid β 1–42 Peptide Differently than Other 8-Hydroxyquinoline Chelating Drugs

Author:

Summers Kelly L.12ORCID,Roseman Graham3,Schilling Kevin M.3,Dolgova Natalia V.1,Pushie M. Jake4ORCID,Sokaras Dimosthenis5,Kroll Thomas5,Harris Hugh H.6ORCID,Millhauser Glenn L.3ORCID,Pickering Ingrid J.12ORCID,George Graham N.12ORCID

Affiliation:

1. Molecular and Environmental Sciences Group, Department of Geological Sciences, College of Arts and Science, University of Saskatchewan, 114 Science Place, Saskatoon, SaskatchewanS7N 5E2, Canada

2. Department of Chemistry, College of Arts and Science, University of Saskatchewan, 110 Science Place, Saskatoon, SaskatchewanS7N 5C9, Canada

3. Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California95064, United States

4. Department of Surgery, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SaskatchewanS7N 0W8, Canada

5. Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California94025, United States

6. Department of Chemistry, University of Adelaide, Adelaide, SA5005, Australia

Funder

U.S. Department of Health and Human Services

U.S. Department of Energy

Canada Foundation for Innovation

Department of Education and Training

Canada Research Chairs

University of Saskatchewan

Government of Canada

National Institute of Health

Province of Saskatchewan

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Physical and Theoretical Chemistry

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