Unique Base-Step Recognition by a Platinum−Acridinylthiourea Conjugate Leads to a DNA Damage Profile Complementary to That of the Anticancer Drug Cisplatin
Author:
Affiliation:
1. Department of Chemistry, Wake Forest University, P.O. Box 7486 Reynolda Station, Winston-Salem, North Carolina 27109
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi049415d
Reference34 articles.
1. Design, Synthesis, and Biological Activity of a Novel Non-Cisplatin-type Platinum−Acridine Pharmacophore
2. Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells
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2. Thermodynamic Insights by Microscale Thermophoresis into Translesion DNA Synthesis Catalyzed by DNA Polymerases Across a Lesion of Antitumor Platinum–Acridine Complex;International Journal of Molecular Sciences;2020-10-21
3. Cysteine-Directed Bioconjugation of a Platinum(II)–Acridine Anticancer Agent;Inorganic Chemistry;2018-12-13
4. Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors;European Journal of Medicinal Chemistry;2018-07
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