Single-Cell Sequencing-Enabled Hexokinase 2 Assay for Noninvasive Bladder Cancer Diagnosis and Screening by Detecting Rare Malignant Cells in Urine

Author:

Wang Zhuo1,Chen Jie2,Yang Liu3,Cao Mingzhe4,Yu Yanlan5,Zhang Rulin6,Quan Heng6,Jiang Qi7,Hua Yingqi3,Wei Wei8,Lu Peihua9,Wu Jun10,Shi Qihui111ORCID

Affiliation:

1. Minhang Branch, Zhongshan Hospital and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 201100, China

2. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China

3. Shanghai Bone Tumor Institute and Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

4. The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China

5. Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China

6. Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

7. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

8. Institute for Systems Biology, Seattle 98109, Washington, United States

9. Department of Medical Oncology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

10. Department of Clinical Laboratory, Shanghai General Hospital Jiading Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China

11. Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital & AHS, Fudan University, Shanghai 201100, China

Funder

Washington Research Foundation

China Postdoctoral Science Foundation

Government of Jiangsu Province

Jiangsu Provincial Commission of Health and Family Planning

National Natural Science Foundation of China

Wuxi Health and Family Planning Commission

Andy Hill CARE Fund

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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