Normalization Approach by a Reference Material to Improve LC–MS-Based Metabolomic Data Comparability of Multibatch Samples

Author:

Yao Yao1ORCID,Zhang Hui234,Tu Lanyin1,Yu Tiantian2,Chen Baowei5ORCID,Huang Peng62,Hu Yumin62ORCID,Luan Tiangang17ORCID

Affiliation:

1. Sate Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou510275, China

2. Metabolic Innovation Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou510080, China

3. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China

4. Platform of Metabolomics, Center for Precision Medicine, Sun Yat-Sen University, Guangzhou510080, China

5. Southern Marine Science and Engineering Guangdong Laboratory, School of Marine Sciences, Sun Yat-Sen University, Zhuhai519082, China

6. State Key Laboratory of Oncology in South China, Cancer Metabolism and Intervention Research Center, Sun Yat-Sen University Cancer Center, Guangzhou510060, China

7. Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou510006, China

Funder

National Natural Science Foundation of China

Key R&D Program of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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