Stereodivergent Construction of 3,3′-Disubstituted Oxindoles via One-Pot Sequential Allylation/Alkylation and Its Application to the Total Synthesis of Trigolute B and D-Reference-Cited by-同舟云学术

Stereodivergent Construction of 3,3′-Disubstituted Oxindoles via One-Pot Sequential Allylation/Alkylation and Its Application to the Total Synthesis of Trigolute B and D

Published:2025-01-28 Issue:9 Volume:147 Page:7729-7740
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Qing Bin¹,Yang Zhuang²³^ORCID,Wu Zhenwei¹,Zhang Zichun¹,Zhou Yuqiao⁴⁵,Yan Xinlong¹,Liu Yangbin¹⁶⁷^ORCID,Feng Xiaoming¹⁴⁵^ORCID

Affiliation:

1. Institute of Chemical Biology, Shenzhen Bay Laboratory

2. Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital

3. Sichuan University and Collaborative Innovation Center of Biotherapy

4. Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry

5. Sichuan University

6. State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics

7. Peking University Shenzhen Graduate School

Funder

Guangdong Provincial Pearl River Talents Program

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Shenzhen Bay Laboratory

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.4c17425

Reference83 articles.

1. Importance of Drug Enantiomers in Clinical Pharmacology

2. Biological significance of the enantiomeric purity of drugs

3. Stereochemical aspects of drug action and disposition

4. Putting chirality to work: the strategy of chiral switches

5. The importance of stereoselective determination of drugs in the clinical laboratory

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