Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

Author:

Åslund Andreas1,Sigurdson Christina J.2,Klingstedt Therése1,Grathwohl Stefan3,Bolmont Tristan3,Dickstein Dara L.45,Glimsdal Eirik6,Prokop Stefan7,Lindgren Mikael6,Konradsson Peter1,Holtzman David M.8,Hof Patrick R.45,Heppner Frank L.7,Gandy Samuel59,Jucker Mathias3,Aguzzi Adriano2,Hammarström Per1,Nilsson K. Peter R.12

Affiliation:

1. Department of Chemistry, IFM, Linköping University, SE-581 83 Linköping, Sweden

2. Institute of Neuropathology, Department of Pathology, Universitätsspital Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland

3. Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany

4. Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029

5. Alzheimer’s Disease Research Center, Mount Sinai School of Medicine, New York, New York 10029

6. Department of Physics, Norwegian University of Science and Technology, N-7491 Trondheim, Norway

7. Department of Neuropathology, Charité-Universitätsmedizin Berlin, D-13353 Berlin, Germany

8. Department of Neurology, Alzheimer’s Disease Research Center, Washington University, St. Louis, Missouri 63110

9. Departments of Neurology and Psychiatry, Mount Sinai School of Medicine, New York, New York 10029

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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