Structural Insights into the ATP Binding Pocket of the Anaplastic Lymphoma Kinase by Site-Directed Mutagenesis, Inhibitor Binding Analysis, and Homology Modeling-Reference-Cited by-同舟云学术

Structural Insights into the ATP Binding Pocket of the Anaplastic Lymphoma Kinase by Site-Directed Mutagenesis, Inhibitor Binding Analysis, and Homology Modeling

Published:2006-08-23 Issue:19 Volume:49 Page:5759-5768
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gunby Rosalind H.¹,Ahmed Shaheen¹,Sottocornola Roberta¹,Gasser Marc¹,Redaelli Sara¹,Mologni Luca¹,Tartari Carmen J¹,Belloni Valentina¹,Gambacorti-Passerini Carlo¹,Scapozza Leonardo¹

Affiliation:

1. Department of Clinical Medicine, Via Cadore 48, University of Milano-Bicocca, Monza, 20052, Italy, Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland, Department of Experimental Oncology, Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy, and Department of Oncology, McGill University, Montreal, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060380k

Reference46 articles.

1. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

2. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

3. Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

4. ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases

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