Discovery of N-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain-Reference-Cited by-同舟云学术

Discovery of N-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain

Published:2011-10-05 Issue:20 Volume:54 Page:7408-7416
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Annedi Subhash C.¹,Maddaford Shawn P.¹,Mladenova Gabriela¹,Ramnauth Jailall¹,Rakhit Suman¹,Andrews John S.¹,Lee David K. H.²,Zhang Dongqin³,Porreca Frank³,Bunton David⁴,Christie Lee⁴

Affiliation:

1. NeurAxon Inc., 2395 Speakman Drive, Suite 1001, Mississauga, Ontario, L5K 1B3, Canada

2. NoAb BioDiscoveries Inc., 2820 Argentia Road, Mississauga, Ontario, L5N 8G4, Canada

3. Department of Pharmacology, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724, United States

4. Biopta Ltd., Weipers Centre, Garscube Estate, Bearsden Road, Glasgow G61 1QH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201063u

Reference36 articles.

1. Measurement of Phosphorylated Extracellular Signal–Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology

2. Nitric oxide synthases: structure, function and inhibition

3. STRUCTURE-FUNCTION ASPECTS IN THE NITRIC OXIDE SYNTHASES

4. Nitric oxide in primary headaches

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