1. Department of Genetics and Microbiology, University of Pavia, via Ferrata 1, Pavia, 27100 Italy, Department of Biochemistry, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, Newron Pharmaceuticals Spa, Bresso (MI), Italy, Dipartimento Farmaco-Chimico, University of Bari, via Orabona 4, Bari, 70125 Italy