Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94158, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml400204n
Reference28 articles.
1. Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
2. Inhibition of HSP70: A challenging anti-cancer strategy
3. The HSP70 chaperone machinery: J proteins as drivers of functional specificity
4. Molecular chaperones regulate p53 and suppress senescence programs
5. Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents
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