1. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, No. 110, Section 1, Chien-Kauo N. Road, Taichung 402, Taiwan, ROC, Department of Biological Science and Technology, Chung Hwa University of Medical Technology, No. 89, Wen-Hwa first Street, Jen-Te, Tainan 717, Taiwan, ROC, and Department of Holistic Wellness, Ming Dao University, No. 369, Wen-Hua Road, Peetow, ChangHua 523, Taiwan, ROC