Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 2. Identification and Structure−Activity Relationships of a Novel Series of N-Alkyl-N-(heteroaryl-substituted benzyl)-N‘-arylureas-Reference-Cited by-同舟云学术

Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 2. Identification and Structure−Activity Relationships of a Novel Series of N-Alkyl-N-(heteroaryl-substituted benzyl)-N‘-arylureas

Published:1998-05-23 Issue:13 Volume:41 Page:2390-2410
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tanaka Akira¹,Terasawa Takeshi¹,Hagihara Hiroyuki¹,Sakuma Yuri¹,Ishibe Noriko¹,Sawada Masae¹,Takasugi Hisashi¹,Tanaka Hirokazu¹

Affiliation:

1. Medicinal Chemistry Research Laboratories, Medicinal Biology Research Laboratories, and New Drug Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka 532, Japan, and Exploratory Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-26, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9800853

Reference54 articles.

1. A portion of this work was communicated in a preliminary form: Tanaka, A.; Terasawa, T.; Hagihara, H.; Kinoshita, T.; Sakuma, Y.; Ishibe, N.; Sawada, M.; Takasugi, H.; Tanaka, H. Synthesis, X-ray Crystal Structure, and Biological Activity of FR186054, a Novel, Potent, Orally Active Inhibitor of Acyl-CoA:CholesterolO-Acyltransferase (ACAT) Bearing a Pyrazole Ring.Bioorg. Med. Chem. Lett.1998,8, 81−86.

2. Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease

3. New approaches to atherosclerosis: An overview

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