1. Department of Chemistry, University of Joensuu, Joensuu, Finland; Department of Ophthalmology, Tampere University Hospital, Tampere, Finland; Santen Oy, Tampere, Finland; The Immunopharmacology Research Group, University of Tampere Medical School, Tampere University Hospital, Tampere, Finland; and Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland