Observation of Oligomeric States Indicates a High Structural Flexibility Required for the Onset of Polyglutamine Fibrillization
Author:
Affiliation:
1. Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany
Funder
Deutsche Forschungsgemeinschaft
Konstanz Research School Chemical Biology
Publisher
American Chemical Society (ACS)
Subject
General Materials Science,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.2c00203
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1. Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation
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3. Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
4. Aggregation Kinetics of Interrupted Polyglutamine Peptides
5. Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity
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