<i>In Vivo</i> and <i>In Vitro</i> Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells-Reference-Cited by-同舟云学术

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In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells

Published:2024-04-16 Issue:5 Volume:37 Page:671-674
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Uehara Shotaro¹,Murayama Norie²,Higuchi Yuichiro¹,Shimizu Makiko²,Suemizu Hiroshi¹,Guengerich F. Peter³^ORCID,Yamazaki Hiroshi²^ORCID

Affiliation:

1. Central Institute for Experimental Medicine and Life Science, Kawasaki-ku, Kawasaki 210-0821, Japan

2. Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan

3. Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States

Funder

Japan Society for the Promotion of Science

Ministry of Health, Labour and Welfare

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.4c00069

Reference18 articles.

1. Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite.

2. Thalidomide Metabolism and Hydrolysis: Mechanisms and Implications

3. Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

4. Human Liver Microsomal Cytochrome P450 3A Enzymes Involved in Thalidomide 5-Hydroxylation and Formation of a Glutathione Conjugate

5. In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

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