A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit

Author:

Skiba Meredith A.12,Sikkema Andrew P.12,Moss Nathan A.3,Tran Collin L.1,Sturgis Rebecca M.1,Gerwick Lena3,Gerwick William H.34ORCID,Sherman David H.1567ORCID,Smith Janet L.12ORCID

Affiliation:

1. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States

5. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

6. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

7. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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