Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)-Reference-Cited by-同舟云学术

Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

Published:2019-06-26 Issue:9 Volume:14 Page:2006-2013
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

François-Moutal Liberty¹²,Felemban Razaz¹²³,Scott David D.¹²,Sayegh Melissa R.⁴⁵⁶,Miranda Victor G.¹²,Perez-Miller Samantha¹²,Khanna Rajesh¹^ORCID,Gokhale Vijay⁷,Zarnescu Daniela C.⁴⁵⁶,Khanna May¹²^ORCID

Affiliation:

1. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States

2. Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona 85721, United States

3. King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard, Jeddah, Kingdom of Saudi Arabia

4. Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, United States

5. Department of Neuroscience, University of Arizona, Tucson, Arizona 85721, United States

6. Department of Neurology, University of Arizona, Tucson Arizona 85721, United States

7. Bio5 Institute, University of Arizona, Tucson, Arizona 85721, United States

Funder

National Institute of Neurological Disorders and Stroke

Arizona Disease Control Research Commission

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00481

Reference41 articles.

1. TDP-43 Proteinopathies: Neurodegenerative Protein Misfolding Diseases without Amyloidosis

2. Functional Significance of TDP-43 Mutations in Disease

3. Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

4. TDP-43 is recruited to stress granules in conditions of oxidative insult

5. TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

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