Probing the Flexibility of an Iterative Modular Polyketide Synthase with Non-Native Substrates in Vitro-Reference-Cited by-同舟云学术

Probing the Flexibility of an Iterative Modular Polyketide Synthase with Non-Native Substrates in Vitro

Published:2018-06-18 Issue:8 Volume:13 Page:2261-2268
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Curran Samuel C.¹²^ORCID,Hagen Andrew¹,Poust Sean¹,Chan Leanne Jade G.¹²,Garabedian Brett M.¹²,de Rond Tristan¹²,Baluyot Marian-Joy¹²,Vu Jonathan T.¹²,Lau Andrew K.¹,Yuzawa Satoshi¹²^ORCID,Petzold Christopher J.¹²,Katz Leonard¹²,Keasling Jay D.²³⁴^ORCID

Affiliation:

1. Joint Bioenergy Institute, 5885 Hollis Street, Emeryville California 94608, United States

2. Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States

3. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark

4. Center for Synthetic Biochemistry, Institute for Synthetic Biology, Shenzhen Institutes for Advanced Technologies, Shenzhen, China

Funder

Division of Molecular and Cellular Biosciences

Biological and Environmental Research

Office of Energy Efficiency and Renewable Energy

Division of Engineering Education and Centers

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.8b00422

Reference46 articles.

1. Chapter 6 The DEBS Paradigm for Type I Modular Polyketide Synthases and Beyond

2. The Structural Basis for Docking in Modular Polyketide Biosynthesis

3. Evolution of metabolic diversity: Insights from microbial polyketide synthases

4. The structures of type I polyketide synthases

5. Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

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