4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth-Reference-Cited by-同舟云学术

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth

Published:2014-01-22 Issue:3 Volume:57 Page:1063-1078
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Foley Timothy L.¹,Rai Ganesha¹,Yasgar Adam¹,Daniel Thomas¹,Baker Heather L.¹,Attene-Ramos Matias¹,Kosa Nicolas M.²,Leister William¹,Burkart Michael D.²,Jadhav Ajit¹,Simeonov Anton¹,Maloney David J.¹

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401752p

Reference63 articles.

1. Drugs for bad bugs: confronting the challenges of antibacterial discovery

2. Challenges of Antibacterial Discovery

3. A new enzyme superfamily — the phosphopantetheinyl transferases

4. Inhibiting Bacterial Fatty Acid Synthesis

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of 2‐Phenyl‐4,6‐bis(trifluoromethyl)pyridine via NH ₄ I/Na ₂ S ₂ O ₄ ‐Mediated Cyclization of Ketoxime Acetates;Organic Syntheses;2024-08

2. Synthesis, Kinetics and Computational Explorations of 4‐Phenylpiperazine Bearing N‐(Aryl)‐3‐substituted‐benzamides as Auspicious Tyrosinase Inhibitors;Chemistry & Biodiversity;2024-03-13

3. New quinoxaline‐piperazine‐oxazole conjugates: Synthesis, in vitro anticancer, in silico ADMET, and molecular docking studies;Journal of Heterocyclic Chemistry;2024-02-05

4. Design, synthesis, molecular docking, molecular dynamic simulation, and MMGBSA analysis of 7-O-substituted 5-hydroxy flavone derivatives;Journal of Biomolecular Structure and Dynamics;2023-08-07

5. An insight into the biological activity and structure-based drug design attributes of sulfonylpiperazine derivatives;Journal of Molecular Structure;2023-04