Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5-Reference-Cited by-同舟云学术

Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5

Published:2016-11-08 Issue:47 Volume:55 Page:6558-6567
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Pearl Naw May¹,Wilcoxen Jarett²,Im Sangchoul¹,Kunz Ryan³,Darty Joseph³,Britt R. David²,Ragsdale Stephen W.³,Waskell Lucy¹

Affiliation:

1. Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0112, United States

2. Department of Chemistry, University of California, Davis, Davis, California 95616, United States

3. Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600, United States

Funder

U.S. Department of Veterans Affairs

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.6b00996

Reference62 articles.

1. Human Cytochrome P450 Enzymes

2. Unusual Cytochrome P450 Enzymes and Reactions

3. The Function of Tyrosine 74 of Cytochrome b5

4. Cytochrome b5 Increases the Rate of Product Formation by Cytochrome P450 2B4 and Competes with Cytochrome P450 Reductase for a Binding Site on Cytochrome P450 2B4

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