An N-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy-Reference-Cited by-同舟云学术

An N-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy

Published:2019-12-31 Issue:3 Volume:31 Page:501-506
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Cheal Sarah M.¹,Patel Mitesh¹,Yang Guangbin²,Veach Darren³,Xu Hong⁴,Guo Hong-fen⁴,Zanzonico Pat B.⁵,Axworthy Donald B.⁶,Cheung Nai-Kong V.⁴,Ouerfelli Ouathek²,Larson Steven M.¹³^ORCID

Affiliation:

1. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

2. Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

3. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

4. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

5. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

6. Eurofins Panlabs, Bothell, Washington 98011, United States

Funder

National Cancer Institute

National Institutes of Health

Enid A. Haupt Chair

Donna & Benjamin M. Rosen Chair

Mr. William H. Goodwin and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research

Center for Targeted Radioimmunotherapy and Theranostics, Ludwig Center for Cancer Immunotherapy of Memorial Sloan Kettering (MSK) Cancer Center

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.9b00736

Reference21 articles.

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2. Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

3. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

4. Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma

5. Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD2 Using an IgG-scFv Bispecific Antibody with High Affinity for GD2 and DOTA Metal Complex

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