Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)-Reference-Cited by-同舟云学术

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Published:2012-08-08 Issue:16 Volume:55 Page:7193-7207
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Axten Jeffrey M.¹,Medina Jesús R.¹,Feng Yanhong¹,Shu Arthur¹,Romeril Stuart P.¹,Grant Seth W.¹,Li William Hoi Hong¹,Heerding Dirk A.¹,Minthorn Elisabeth¹,Mencken Thomas¹,Atkins Charity¹,Liu Qi¹,Rabindran Sridhar¹,Kumar Rakesh¹,Hong Xuan,Goetz Aaron,Stanley Thomas,Taylor J. David,Sigethy Scott D.,Tomberlin Ginger H.,Hassell Annie M.,Kahler Kirsten M.,Shewchuk Lisa M.,Gampe Robert T.

Affiliation:

1. Oncology Research, Protein Dynamics DPU, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300713s

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