Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen-Reference-Cited by-同舟云学术

Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen

Published:2022-09-28 Issue:10 Volume:5 Page:993-1006
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Clausse Victor¹,Fang Yuhong²,Tao Dingyin²^ORCID,Tagad Harichandra D.³,Sun Hongmao²^ORCID,Wang Yuhong²^ORCID,Karavadhi Surendra²,Lane Kelly⁴,Shi Zhen-Dan⁴,Vasalatiy Olga⁴,LeClair Christopher A.²^ORCID,Eells Rebecca⁵,Shen Min²^ORCID,Patnaik Samarjit²^ORCID,Appella Ettore³,Coussens Nathan P.⁶,Hall Matthew D.²^ORCID,Appella Daniel H.¹^ORCID

Affiliation:

1. Synthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States

2. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States

3. Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, United States

4. Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland 20850, United States

5. Reaction Biology Corporation, 1 Great Valley Parkway, Suite 2, Malvern, Pennsylvania 19355, United States

6. Molecular Pharmacology Laboratories, Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00147

Reference81 articles.

1. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

2. Kinase-targeted cancer therapies: progress, challenges and future directions

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5. New Approaches to Difficult Drug Targets: The Phosphatase Story

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