Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

Author:

Li Jihong1,Fukase Yoshiyuki2,Shang Yi3,Zou Wei4,Muñoz-Félix José M.5,Buitrago Lorena1,van Agthoven Johannes6,Zhang Yixiao7,Hara Ryoma2,Tanaka Yuta2,Okamoto Rei2,Yasui Takeshi2ORCID,Nakahata Takashi2,Imaeda Toshihiro2,Aso Kazuyoshi2,Zhou Yuchen3,Locuson Charles8,Nesic Dragana1,Duggan Mark9,Takagi Junichi10,Vaughan Roger D.11,Walz Thomas7,Hodivala-Dilke Kairbaan5,Teitelbaum Steven L.4,Arnaout M. Amin6,Filizola Marta3ORCID,Foley Michael A.2,Coller Barry S.1ORCID

Affiliation:

1. Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, United States

2. Tri-Institutional Therapeutics Discovery Institute, 413 East 69 Street, New York, New York 10021, United States

3. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1677, New York, New York 10029-6574, United States

4. Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, Missouri 63110, United States

5. Adhesion and Angiogenesis Laboratory, Centre for Tumour Biology, Barts Cancer Institute—a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, United Kingdom

6. Leukocyte Biology and Inflammation and Structural Biology Programs, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, United States

7. Laboratory of Molecular Electron Microscopy, Rockefeller University, 1230 York Avenue, New York, New York 10065, United States

8. Agios Pharmaceuticals, 88 Sidney Street, Cambridge, Massachusetts 02139-4169, United States

9. LifeSci Consulting, LLC, 18243 SE Ridgeview Drive, Tequesta, Florida 33469, United States

10. Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan

11. Rockefeller University Center for Clinical and Translational Science, Rockefeller University, 2130 York Avenue, New York, New York 10065, United States

Funder

National Center for Advancing Translational Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Worldwide Cancer Research

National Heart, Lung, and Blood Institute

Stony Brook University

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Cancer Research UK

National Science Foundation

Tri-Institutional Therapeutic Discovery Institute

Robertson Discovery Fund

Shriners Hospital for Children

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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