Novel Peptide DR3penA as a Low-Toxicity Antirenal Fibrosis Agent by Suppressing the TGF-β1/miR-212-5p/Low-Density Lipoprotein Receptor Class a Domain Containing 4/Smad Axis

Author:

Deng Bochuan1ORCID,Zhang Jiao1,Zhang Xiang1,Wang Dan2,Cheng Lu3,Su Ping1,Yu Tingli1,Bao Guangjun1,Li Guofeng4ORCID,Hong Liang5ORCID,Miao Xiaokang1,Yang Wenle1,Wang Rui16ORCID,Xie Junqiu1ORCID

Affiliation:

1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, China

2. Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong 637000, China

3. School of Biomedical Engineering, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen 518060, China

4. School of Pharmaceutical Sciences, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen 518060, China

5. Guangdong Provincial Key Laboratory of Chiral Molecular and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

6. Institute of Materia Medica and Research Unit of Peptide Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Funder

Ministry of Education of the People's Republic of China

Chinese Academy of Medical Sciences

Science and Technology Program of Gansu Province

Fundamental Research Funds for the Central Universities

Guangdong Provincial Key Laboratory of Construction Foundation

Doctoral Scientific Research Fund of North Sichuan Medical College

Publisher

American Chemical Society (ACS)

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