Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors-Reference-Cited by-同舟云学术

Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors

Published:2022-11-02 Issue:11 Volume:5 Page:1156-1168
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Sousa Bárbara B.¹,de Almeida Cátia Rebelo²,Barahona Ana F.²,Lopes Raquel²,Martins-Logrado Ana²,Cavaco Marco¹^ORCID,Neves Vera¹^ORCID,Carvalho Luís A. R.³,Labão-Almeida Carlos¹,Coelho Ana R.¹,Leal Bento Marta¹⁴,Lopes Ricardo M. R. M.⁵,Oliveira Bruno L.¹,Castanho Miguel A. R. B.¹^ORCID,Neumeister Peter⁶,Deutsch Alexander⁶,Vladimer Gregory I.⁷^ORCID,Krall Nikolaus⁷,João Cristina²,Corzana Francisco⁸^ORCID,Seixas João D.¹⁹,Fior Rita²,Bernardes Gonçalo J. L.¹³^ORCID

Affiliation:

1. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof. Egas Moniz, 1649-028, Lisbon, Portugal

2. Champalimaud Foundation, Avenida de Brasília, 1400-038, Lisbon, Portugal

3. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

4. Centro Hospitalar Lisboa Norte, Department of Hematology and Bone Marrow Transplantation, Avenida Prof. Egas Moniz, 1649-035 Lisbon, Portugal

5. Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1600-277 Lisbon, Portugal

6. Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, 8036 Graz, Austria

7. Exscientia, The Schrödinger Building, Oxford Science Park, Oxford OX4 4GE, U.K.

8. Centro de Investigación en Síntesis Química, Departamento de Química, Universidad de La Rioja, 26006 Logroño, Spain

9. TARGTEX S.A., Avenida Tenente Valadim, N°17, 2F, 2560-275 Torres Vedras, Portugal

Funder

European Regional Development Fund

H2020 Marie Sklodowska-Curie Actions

Funda??o para a Ci?ncia e a Tecnologia

H2020 Spreading Excellence and Widening Participation

Agencia Estatal de Investigaci?n, Ministerio de Ciencia, Innovaci?n y Universidades

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00163

Reference49 articles.

1. Role of Bruton’s tyrosine kinase in B cells and malignancies

2. T-cell expression of Bruton’s tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia

3. Expression of Bruton's tyrosine kinase protein within the B cell lineage

4. Bruton’s Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus

5. Phosphatidylinositol 3-kinase- activates Bruton's tyrosine kinase in concert with Src family kinases

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