Multivalent Vaccination Strategies Protect against Exposure to Polydrug Opioid and Stimulant Mixtures in Mice and Rats

Author:

Song Daihyun1ORCID,Crouse Bethany12ORCID,Vigliaturo Jennifer1,Wu Mariah M.12,Heimisdottir Dagny1,Kassick Andrew J.3,Averick Saadyah E.34,Raleigh Michael D.1,Pravetoni Marco156

Affiliation:

1. Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States

2. School of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55455, United States

3. Neuroscience Disruptive Research Lab, Allegheny Health Network Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States

4. Neuroscience Institute, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States

5. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, United States

6. University of Washington Center for Medication Development for Substance Use Disorders; Garvey Institute for Brain Solutions, Seattle,Washington 98195, United States

Funder

National Institute on Drug Abuse

University of Minnesota

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Reference47 articles.

1. Centers for Disease Control and Prevention. U.S. Overdose Deaths In 2021 Increased Half as Much as in 2020 – But Are Still Up 15%, May 11 2022. https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2022/202205.htm (accessed 2023–02–27).

2. Vital Signs: Characteristics of Drug Overdose Deaths Involving Opioids and Stimulants — 24 States and the District of Columbia, January–June 2019

3. Mechanisms of fatal opioid overdose

4. Opioids, Ventilation and Acute Pain Management

5. Respiratory and haemodynamic effects of acute postoperative pain management: evidence from published data

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