Selective Targeting of Vascular Endothelial YAP Activity Blocks EndMT and Ameliorates Unilateral Ureteral Obstruction-Induced Kidney Fibrosis

Author:

Ren Yafeng1,Zhang Yuwei23,Wang Lu23,He Fuqian4,Yan Mengli1,Liu Xiaoheng23,Ou Yangying23,Wu Qinkai5,Bi Tao23,Wang Shiyuan23,Liu Jian23,Ding Bi-Sen167,Wang Li3,Qing Jie231ORCID

Affiliation:

1. Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu 610064, China

2. National Traditional Chinese Medicine Clinical Research Base, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, China

3. Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, China

4. The Center of Gerontology and Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China

5. Michael Smith Laboratories, University of British Columbia, Vancouver V6T1Z4, Canada

6. Fibrosis Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10128, United States

7. Ansary Stem Cell Institute, Weill Cornell Medicine, New York, New York 10065, United States

Funder

Department of Science and Technology of Sichuan Province

National Natural Science Foundation of China

Science and Technology Strategic Cooperation Project of Luzhou Municipal People's Government-Southwest Medical University

Joint Project of Southwest Medical University and Affiliated Traditional Medicine Hospital of Southwest Medical University

Luzhou Municipal-Southwest Medical University Joint Special Grant for the Introduction of High-Level Talents

Luzhou-Southwest Medical Joint Platform Project

Natural science project of Southwest Medical University

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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