Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure–Activity Relationships and Mechanism of Action

Author:

Boyer Zachary W.1,Kessler Hannah1,Brosman Hannah1,Ruud Kirsten J.2,Falkowski Alan F.2,Viollet Constance1,Bourne Christina R.3ORCID,O’Reilly Matthew C.1ORCID

Affiliation:

1. Department of Chemistry, Villanova University, Villanova, Pennsylvania 19085, United States

2. Department of Chemistry and Biotechnology, University of Wisconsin−River Falls, River Falls, Wisconsin 54022, United States

3. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States

Funder

Villanova University

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference42 articles.

1. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

2. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2013; U.S. Department of Health and Human Services: Atlanta, GA, 2013.

3. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United State, 2019; U.S. Department of Health and Human Services: Atlanta, GA, 2019.

4. β-Lactams and β-Lactamase Inhibitors: An Overview

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