Screen of the ReFRAME Compound Library for Therapeutic Agents to Prevent Red Blood Cell Sickling Using an Improved High Throughput Sickling Assay-Reference-Cited by-同舟云学术

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Screen of the ReFRAME Compound Library for Therapeutic Agents to Prevent Red Blood Cell Sickling Using an Improved High Throughput Sickling Assay

Published:2025-04-14 Issue:16 Volume:10 Page:16497-16505
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Nakagawa Akito¹²^ORCID,Morwood Kaycie³⁴,Johnson Kristen³⁴^ORCID,Berra Lorenzo¹²,Boal Lauren⁵²,Azar Sharl⁶²,Huang Mary⁵²,Heeney Matthew M.⁷,Bloch Donald B.¹²⁸²,Ichinose Fumito¹²

Affiliation:

1. Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine

2. Massachusetts General Hospital and Harvard Medical School

3. The Calibr-Skaggs Institute for Innovative Medicines

4. Scripps Research

5. Division of Pediatric Hematology and Oncology

6. Comprehensive Sickle Cell Disease Treatment Center

7. Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School

8. Division of Rheumatology, Allergy and Immunology, Department of Medicine

Funder

U.S. Department of Health and Human Services

Gates Family Foundation

Wellcome Trust

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c11077

Reference51 articles.

1. Sickle cell disease

2. Sickle Cell Disease

3. Sickle Cell Hemoglobin Polymerization

4. Sickle Hemoglobin Polymerization in Solution and in Cells

5. Intravascular hemolysis and the pathophysiology of sickle cell disease

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