Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding

Author:

McCarthy Michael J.12,Pagba Cynthia V.1,Prakash Priyanka1,Naji Ali K.3,van der Hoeven Dharini3,Liang Hong1,Gupta Amit K.1,Zhou Yong12,Cho Kwang-Jin4,Hancock John F.12,Gorfe Alemayehu A.12ORCID

Affiliation:

1. Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, Texas 77030, United States

2. Biochemistry and Cell Biology Program, UTHealth MD Anderson Cancer Center Graduate School of Biomedical Sciences, 6431 Fannin Street, Houston, Texas 77030, United States

3. Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Cambridge Street, Houston, Texas 7500, United States

4. Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio 45435, United States

Funder

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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