Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues-Reference-Cited by-同舟云学术

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues

Published:2019-06-10 Issue:6 Volume:4 Page:10056-10069
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Toulouse Jacynthe L.¹²,Yachnin Brahm J.¹³,Ruediger Edward H.,Deon Daniel,Gagnon Marc,Saint-Jacques Kévin⁴,Ebert Maximilian C. C. J. C.⁵,Forge Delphine⁶,Bastien Dominic¹²,Colin Damien Y.¹²,Vanden Eynde Jean Jacques⁶,Marinier Anne,Berghuis Albert M.¹³,Pelletier Joelle N.¹²^ORCID

Affiliation:

1. PROTEO, the Québec Network for Research on Protein, Function, Engineering and Applications, Quebec G1V 0A6, Canada

2. CGCC, The Center in Green Chemistry and Catalysis, Montréal H3A 0B8, Quebec, Canada

3. Department of Biochemistry, McGill University, Montréal H3A 0G4, Quebec, Canada

4. Département de Chimie, Université de Sherbrooke, Sherbrooke J1K 0A5, Quebec, Canada

5. Chemical Computing Group, Montreal H3A 2R7, Quebec, Canada

6. Laboratoire de Chimie Organique, Université de Mons, Mons 7000, Belgium

Funder

Canadian Institutes of Health Research

Hydro-Qu?bec

Canada Foundation for Innovation

McGill University

Fonds Qu?b?cois de la Recherche sur la Nature et les Technologies

Natural Sciences and Engineering Research Council of Canada

Fondation Marcel et Rolande Gosselin

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsomega.9b00640

Reference53 articles.

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2. World Health Organization, WHO. WHO list of critically important antimicrobials for human medicine.

3. History and Future of Antimicrobial Diaminopyrimidines

4. Investigation of Classical Organic and Ionic Liquid Cosolvents for Early-Stage Screening in Fragment-Based Inhibitor Design with Unrelated Bacterial and Human Dihydrofolate Reductases

5. Trimethoprim-Sulfamethoxazole Revisited

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