Practical and Facile Access to Bicyclo[3.1.1]heptanes: Potent Bioisosteres of <i>meta</i>-Substituted Benzenes-Reference-Cited by-同舟云学术

Practical and Facile Access to Bicyclo[3.1.1]heptanes: Potent Bioisosteres of meta-Substituted Benzenes

Published:2022-11-07 Issue:48 Volume:144 Page:21848-21852
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Iida Toranosuke¹,Kanazawa Junichiro¹,Matsunaga Tadafumi¹,Miyamoto Kazunori¹^ORCID,Hirano Keiichi¹^ORCID,Uchiyama Masanobu¹²^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

2. Research Initiative for Supra-Materials (RISM), Shinshu University, 3-15-1 Tokida, Ueda, Nagano 386-8567, Japan

Funder

Naito Foundation

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Nagase Science Technology Foundation

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Uehara Memorial Foundation

Chugai Pharmaceutical

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c09733

Reference43 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. Synthesis and biological evaluation of 2-(3′-(1 H -tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine ( S -TBPG), a novel mGlu1 receptor antagonist

3. Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

4. Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

5. Fischer, C.; Bogen, S.; Childers, M. L.; Llinas, F. X. F.; Ellis, J. M. Novel Tricyclic Compounds as Inhibitors of Mutant IDH Enzymes. WO/2016/089830 A1, 2016.

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of Heterocycle-Substituted Bicyclo[3.1.1]heptanes and Aza-bicyclo[3.1.1]heptanes via Photocatalytic Minisci Reaction;Organic Letters;2024-01-22

2. Biological Evaluation of Isosteric Applicability of 1,3‐Substituted Cuneanes as m‐Substituted Benzenes Enabled by Selective Isomerization of 1,4‐Substituted Cubanes;Chemistry – A European Journal;2024-01-11

3. C−F bond activation enables synthesis of aryl difluoromethyl bicyclopentanes as benzophenone-type bioisosteres;Nature Communications;2024-01-10

4. Photocatalyzed [2σ + 2σ] and [2σ + 2π] Cycloadditions for the Synthesis of Bicyclo[3.1.1]heptanes and 5- or 6-Membered Carbocycles;Journal of the American Chemical Society;2023-11-07

5. Silver‐Catalyzed Dearomative [2π+2σ] Cycloadditions of Indoles with Bicyclobutanes: Access to Indoline Fused Bicyclo[2.1.1]hexanes**;Angewandte Chemie International Edition;2023-10-25