Structure of Gas Phase Monohydrated Nicotine: Implications for Nicotine’s Native Structure in the Acetylcholine Binding Protein

Author:

Santis Garrett D.1,Takeda Naoya23,Hirata Keisuke245,Tsuruta Kazuya23,Ishiuchi Shun-ichi246,Xantheas Sotiris S.157ORCID,Fujii Masaaki235ORCID

Affiliation:

1. Department of Chemistry, University of Washington, Seattle, Washington 98195, United States

2. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan

3. School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan

4. Department of Chemistry, School of Science, Tokyo Institute of Technology, 2-12-1 4259 Ookayama, Meguro-ku, Tokyo 152-8550, Japan

5. Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovation Research, Tokyo Institute of Technology, 4259, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan

6. IIR Program for World Research (IPWR), Institute of Innovation Research, Tokyo Institute of Technology, 4259, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan

7. Advanced Computing, Mathematics and Data Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P.O. Box 999, MS K1-83, Richland, Washington 99352, United States

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

U.S. Department of Energy

Tokyo Institute of Technology

RIKEN Pioneering Project

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference40 articles.

1. FACILITATION OF HUMAN TOBACCO SELF-ADMINISTRATION BY ETHANOL: A BEHAVIORAL ANALYSIS1

2. Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

3. Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats

4. Food and Drug Administration, Department of Health and Human Services. Federal Register. https://www.federalregister.gov/documents/2018/03/16/2018-05345/tobacco-product-standard-for-nicotine-level-of-combusted-cigarettes (accessed February 15, 2021).

5. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery

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