Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries-Reference-Cited by-同舟云学术

Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries

Published:2012-11-12 Issue:22 Volume:55 Page:9562-9575
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Suzuki Takayoshi¹²,Ota Yosuke³,Ri Masaki⁴,Bando Masashige⁵,Gotoh Aogu¹³,Itoh Yukihiro¹,Tsumoto Hiroki³,Tatum Prima R.³,Mizukami Tamio⁶,Nakagawa Hidehiko³,Iida Shinsuke⁴,Ueda Ryuzo⁴,Shirahige Katsuhiko⁵,Miyata Naoki³

Affiliation:

1. Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 13 Taishogun Nishitakatsukasa-Cho, Kita-ku, Kyoto 403-8334, Japan

2. PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan

3. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan

4. Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan

5. Institute of Molecular and Cellular Biosciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

6. Graduate School of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga, 526-0829, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300837y

Reference61 articles.

1. Deacetylase Enzymes

2. Acetylation and deacetylation of non-histone proteins

3. Focus on acetylation: the role of histone deacetylase inhibitors in cancer therapy and beyond

4. Epigenetics—An Epicenter of Gene Regulation: Histones and Histone-Modifying Enzymes

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