DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China

Author:

Wan Cong12ORCID,Pan Shangxia3,Lin Lifeng3,Li Jun1ORCID,Dong Guanghui4ORCID,Jones Kevin C.5ORCID,Liu Fei6,Li Daochuan4,Liu Jing7,Yu Zhiqiang1ORCID,Zhang Gan1ORCID,Ma Huimin15ORCID

Affiliation:

1. State Key Laboratory of Organic Geochemistry and Guangdong province Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China

4. Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China

5. Lancaster Environmental Centre, Lancaster University, LA1 4YQ Lancaster, United Kingdom

6. School of Business Administration, South China University of Technology, Guangzhou 510641, China

7. Guangzhou first people’s hospital, Guangzhou 510180, China

Funder

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Guangdong Province

State Key Laboratory of Organic Geochemistry

Guangzhou Science and Technology Program

Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

Reference45 articles.

1. ATSDR (Agency for Toxic Substances and Disease Registry). The ATSDR 2017 Substance Priority List. 2017, http://www.atsdr.cdc.gov/spl/.

2. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood

3. WHO (World Health Organization). Lead poisoning and health. 2018, http://www.who.int/en/news-room/fact-sheets/detail/lead-poisoning-and-health.

4. Exposures to Environmental Toxicants and Attention Deficit Hyperactivity Disorder in U.S. Children

5. Clinical and molecular aspects of lead toxicity: An update

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