Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path-Reference-Cited by-同舟云学术

Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path

Published:2022-10-17 Issue:6 Volume:2 Page:627-641
ISSN:2694-2437
Container-title:ACS Bio & Med Chem Au
language:en
Short-container-title:ACS Bio Med Chem Au

Author:

Bram Yaron¹^ORCID,Duan Xiaohua²,Nilsson-Payant Benjamin E.³,Chandar Vasuretha¹,Wu Hao⁴,Shore Derek⁴,Fajardo Alvaro¹^ORCID,Sinha Saloni¹,Hassan Nora¹,Weinstein Harel⁴^ORCID,TenOever Benjamin R.³,Chen Shuibing²,Schwartz Robert E.¹⁴

Affiliation:

1. Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States

2. Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States

3. Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustav L Levy Place, New York, New York 10029, United States

4. Department of Physiology, Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States

Funder

Defense Advanced Research Projects Agency

National Institute of Diabetes and Digestive and Kidney Diseases

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

New York State Stem Cell Science

Irma T. Hirschl Trust

Department of Surgery, Weill Cornell Medicine

Department of Medicine, Weill Cornell Medicine

Publisher

American Chemical Society (ACS)

Subject

Pharmaceutical Science,Drug Discovery,Molecular Biology,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.2c00034

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1. Origin and evolution of pathogenic coronaviruses

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3. Coronavirus Main Proteinase (3CL pro ) Structure: Basis for Design of Anti-SARS Drugs

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5. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

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