Cytochrome P450 Enzymes as Catalysts of Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a Tobacco Specific Carcinogen-Reference-Cited by-同舟云学术

Cytochrome P450 Enzymes as Catalysts of Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a Tobacco Specific Carcinogen

Published:2005-02-01 Issue:2 Volume:18 Page:95-110
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Jalas John R.¹,Hecht Stephen S.¹,Murphy Sharon E.¹

Affiliation:

1. Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, and The Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx049847p

Reference101 articles.

1. Tobacco carcinogens, their biomarkers and tobacco-induced cancer

2. Jalas, J. R., McIntee, E. J., Kenney, P. M., Upadhyaya, P., Peterson, L. A., and Hecht, S. S. (2003) Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).Chem. Res. Toxicol.16, 794−806.

3. Staretz, M. E., Foiles, P. G., Miglietta, L. M., and Hecht, S. S. (1997) Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: Effects of dose and phenethyl isothiocyanate.Cancer Res.57, 259−266.

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