Spiropiperidine Sultam and Lactam Templates: Diastereoselective Overman Rearrangement and Metathesis followed by NH Arylation-Reference-Cited by-同舟云学术

Spiropiperidine Sultam and Lactam Templates: Diastereoselective Overman Rearrangement and Metathesis followed by NH Arylation

Published:2017-11-13 Issue:23 Volume:82 Page:12246-12256
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Martinez-Alsina Luis A.¹,Murray John C.¹,Buzon Leanne M.¹,Bundesmann Mark W.¹,Young Joseph M.²,O’Neill Brian T.¹^ORCID

Affiliation:

1. Medicine Design, Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States

2. Novartis Institute for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608-2916, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.7b02096

Reference57 articles.

1. aBrodney, M. A., Efremov, I. V., Helal, C. J., and O’Neill, B. T.PCT Int. Appl. WO 2010/58333, 2010.

2. bCoburn, C. A., Egbertson, M. S., Graham, S. L., Mcgaughey, G. B., Stauffer, S. R., Yang, W. L., Lu, W., and Fahr, B.PCT Int. Appl. WO 2007/011810, 2007.

3. Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase‡

4. Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

5. eOrexin inhibitors:Breslin, M. J.; Cox, C. D.; Whitman, D. B.WO2007/25069 A2, 2007.

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