Rapid sp<sup>3</sup>-Enriched Scaffold Generation via a Selective Aziridine Amide Ring-Opening Reaction-Reference-Cited by-同舟云学术

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Rapid sp³-Enriched Scaffold Generation via a Selective Aziridine Amide Ring-Opening Reaction

Published:2024-02-10 Issue:5 Volume:89 Page:3500-3508
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Abe Masahito¹^ORCID,Coleman Jeremy S.¹,Presley Christopher C.¹,Schley Nathan D.²^ORCID,Lindsley Craig W.¹²³^ORCID

Affiliation:

1. Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Franklin, Tennessee 37067, United States

2. Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States

3. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States

Funder

the William K. Warren, Jr. Chair in Medicine

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c02952

Reference52 articles.

1. Fsp3: A new parameter for drug-likeness

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. Escape from Flatland 2: complexity and promiscuity

4. Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

5. CYTOCHROME P450 ACTIVATION OF ARYLAMINES AND HETEROCYCLIC AMINES

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Direct Aryl/Aliphatic Amide Formation through Ring Opening of Non-Activated Aziridines;Synfacts;2024-06-14

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