Reductive Amination Revisited: Reduction of Aldimines with Trichlorosilane Catalyzed by Dimethylformamide─Functional Group Tolerance, Scope, and Limitations-Reference-Cited by-同舟云学术

Reductive Amination Revisited: Reduction of Aldimines with Trichlorosilane Catalyzed by Dimethylformamide─Functional Group Tolerance, Scope, and Limitations

Published:2021-11-29 Issue:2 Volume:87 Page:920-943
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Popov Kirill K.¹,Campbell Joanna L. P.²,Kysilka Ondřej³,Hošek Jan⁴,Davies Christopher D.⁵,Pour Milan⁶^ORCID,Kočovský Pavel¹⁶⁷^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Prague 2, Czech Republic

2. Syngenta, Grangemouth Manufacturing Centre, Earl’s Road, Grangemouth FK3 8XG, U.K.

3. Trelleborg Bohemia, Akademika Bedrny 531/8a, Věkoše, 500 03 Hradec Králové Czech Republic

4. Farmak, Na vlčinci 16/3, Klášterní Hradisko, 77900 Olomouc, Czech Republic

5. AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire SK10 4TF, U.K.

6. Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

7. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo 2, 166 10 Prague 6, Czech Republic

Funder

AstraZeneca

European Commission

European Regional Development Fund

European Cooperation in Science and Technology

Univerzita Karlova v Praze

University of Glasgow

Wenner-Gren Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c01561

Reference218 articles.

1. Berg, J. M.; Tomoczko, J. L.; Stryer, L. Biochemistry, 5th ed. W. H. Freeman and Company: New York, 2002; p 668.

2. Reductive Aminations of Carbonyl Compounds with Borohydride and Borane Reducing Agents

3. Reductive Amination in the Synthesis of Pharmaceuticals

4. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

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