Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Published:1997-04-01 Issue:9 Volume:40 Page:1347-1365
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Penning Thomas D.¹,Talley John J.¹,Bertenshaw Stephen R.¹,Carter Jeffery S.¹,Collins Paul W.¹,Docter Stephen¹,Graneto Matthew J.¹,Lee Len F.¹,Malecha James W.¹,Miyashiro Julie M.¹,Rogers Roland S.¹,Rogier D. J.¹,Yu Stella S.¹,Anderson Gary D.¹,Burton Earl G.¹,Cogburn J. Nita¹,Gregory Susan A.¹,Koboldt Carol M.¹,Perkins William E.¹,Seibert Karen¹,Veenhuizen Amy W.¹,Zhang Yan Y.¹,Isakson Peter C.¹

Affiliation:

1. Departments of Chemistry, Inflammatory Diseases Research, and Molecular Pharmacology, Searle Research and Development, 4901 Searle Parkway, Skokie, Illinois 60077, 700 Chesterfield Parkway North, Chesterfield, Missouri 63198, and 800 North Lindbergh Boulevard, St. Louis, Missouri 63167

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960803q

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4. Haynes, R. C., Jr. Adrenocorticotropic Hormones; Adrenocortical Steroids and Their Synthetic Analogs; Inhibition of the Synthesis and Actions of Adrenocortical Hormones. InThe Pharmacological Basis ofTherapeutics, 8th ed.; Gilman, A. G., Rall, T. W., Nies, A. S., Taylor, P., Eds.; McGraw-Hill: New York, 1993; pp 1442−1452.

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