Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist-Reference-Cited by-同舟云学术

Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

Published:2022-12-10 Issue:1 Volume:14 Page:66-74
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Zhao Jian¹^ORCID,Wang Shimiao¹,Markison Stacy¹,Kim Sun Hee¹,Han Sangdon¹,Chen Mi¹,Kusnetzow Ana Karin¹,Rico-Bautista Elizabeth¹,Johns Michael¹,Luo Rosa¹,Struthers R. Scott¹,Madan Ajay¹,Zhu Yunfei¹,Betz Stephen F.¹

Affiliation:

1. Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, Building #2, San Diego, California 92121, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00431

Reference30 articles.

1. Opportunities in somatostatin research: biological, chemical and therapeutic aspects

2. Nonpeptidyl Somatostatin Agonists Demonstrate That sst2 and sst5 Inhibit Stimulated Growth Hormone Secretion from Rat Anterior Pituitary Cells

3. Acromegaly

4. Mortality in Acromegaly: A Metaanalysis

5. Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas

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